Carbonic Anhydrase

Carbonic Anhydrase Related Products (164):

By Effects:	Inhibitors (154) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-13650

Indisulam	Inhibitor	99.80%
Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15.

HY-B1480

Ethoxzolamide	Inhibitor	99.85%
Ethoxzolamide is a carbonic anhydrase inhibitor with K_i of 1 nM.

HY-N0639

Punicalin	Inhibitor	99.88%
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity.

HY-B0283

Acipimox	Inhibitor	99.58%
Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

HY-B1424

Benzthiazide	Inhibitor	99.70%
Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with K_is of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells.

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Inhibitor	99.79%
4-Chloro-3-sulfamoylbenzoic acid is an inhibitor of human carbonic anhydrase, targeting the cytosolic isoforms hCA I and hCA II (glaucoma-associated), and the transmembrane isoforms hCA IV and hCA IX (tumor hypoxia-induced).

HY-172607

Carbonic anhydrase inhibitor 30	Inhibitor
Carbonic anhydrase inhibitor 30 (compound 17) is an inhibitor of carbonic anhydrase with K_i values of 2.13 μM and 0.161 nM for hCA I and hCA II, respectively^{[1]^.}

HY-172816

Carbonic anhydrase inhibitor 32	Inhibitor
Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective hCA (Carbonic anhydrase ) II/VII inhibitor with the K_i values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I,respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels.

HY-P1775

Carbonic anhydrase, Bovine erythrocytes
Carbonic anhydrase, Bovine erythrocytes (EC 4.2.1.1) is ubiquitous zinc-containing metalloenzyme present in prokaryotes and eukaryotes. Carbonic anhydrase can catalyze reversible conversion of carbon dioxide to bicarbonate and protons. Carbonic anhydrase can be used for the research of cancer, glaucoma, obesity and epilepsy.

HY-76938

Actarit	Inhibitor	99.58%
Actarit, an orally active antirheumatic compound, has the potential to treat type II collagen-induced arthritis.

HY-B0235

Trichlormethiazide	Inhibitor	98.54%
Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model.

HY-B0397

Dichlorphenamide	Inhibitor	98.49%
Dichlorphenamide (Diclofenamide) is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research.

HY-32933

4-Acetylphenylboronic acid	Inhibitor	99.96%
4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC₅₀s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II). 4-Acetylphenylboronic acid can be obtained via mechanochemistry and solvent evaporation. 4-Acetylphenylboronic acid has a loss of the carbonyl group at 500-550 K.

HY-B0483

Tioxolone	Inhibitor	98.24%
Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis.

HY-163109

Carbonic anhydrase inhibitor 16	Inhibitor	98.00%
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (K_i: 28.5 nM, 2.2 nM).

HY-B0562

Methyclothiazide		99.76%
Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.

HY-W074975

CL 5343	Inhibitor	≥98.0%
CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a K_i of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 ??renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer.

HY-108316

Sultiame	Inhibitor	99.11%
Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic agent.

HY-Y0271R

Urea (Standard)
Urea (Standard) is the analytical standard of Urea. This product is intended for research and analytical applications. Urea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

HY-B0782S

Acetazolamide-d₃	Inhibitor	99.95%
Acetazolamide-d₃ is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.

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